Antibiotic therapy in the elderly patients : We can always do better

被引：0
|
作者：
Tolsma, Violaine [1 ]
Gaillat, Jacques [1 ]
Pagani, Leonardo [2 ,3 ]
机构：
[1] Ctr Hosp Annecy Genevois CHANGE, Serv Malad Infect, Annecy, France
[2] Ctr Hosp Annecy Genevois CHANGE, Programme Bon Usage Antimicrobiens, Annecy, France
[3] Hop Cent Bolzano, Serv Malad Infect, I-39100 Bolzano, Italy
来源：
CANADIAN JOURNAL ON AGING-REVUE CANADIENNE DU VIEILLISSEMENT | 2016年 / 35卷 / 03期
关键词：
antimicrobials; pharmacokinetics; pharmacodynamics; elderly patients (subjects); PLASMA-PROTEIN BINDING; AGE-RELATED-CHANGES; RENAL-FUNCTION; PHARMACODYNAMIC CHANGES; SEVERE DYSGLYCEMIA; BODY-MASS; LIVER; RISK; PHARMACOKINETICS; FLUOROQUINOLONES;
D O I：
10.1017/S0714980816000350
中图分类号：
R4 [临床医学]; R592 [老年病学];
学科分类号：
1002 ; 100203 ; 100602 ;
摘要：
Antimicrobials are among the most prescribed drugs and their prescription increases with age, due to frailty and accrued risk factors for acquiring infections. Antimicrobial prescription in elderly patients must not only account for the risk of toxicity due to drug overexposure, but also of treatment failure or promotion of antimicrobial resistance due to under-dosage. This paper reviews the main antimicrobial, pharmacokinetic and pharmacodynamic variations induced by aging, comorbidities and polypharmacy, and how to take them into account to optimize antimicrobial prescription in elders.
引用
收藏
页码：385 / 392
页数：8
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