Autoantibodies against a 43 KDa Muscle Protein in Inclusion Body Myositis

被引：83
|
作者：
Salajegheh, Mohammad [1 ,2 ,3 ]
Lam, Theresa [2 ]
Greenberg, Steven A. [1 ,2 ,3 ]
机构：
[1] Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA
[2] Childrens Hosp Boston, Childrens Hosp Informat Program, Boston, MA USA
[3] Harvard Univ, Sch Med, Boston, MA USA
来源：
PLOS ONE | 2011年 / 6卷 / 05期
关键词：
CLINICALLY AMYOPATHIC DERMATOMYOSITIS; INFLAMMATORY MYOPATHIES; POLYMYOSITIS; PATHOGENESIS; DIAGNOSIS; PROFILES; DISEASE; CELLS;
D O I：
10.1371/journal.pone.0020266
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Inclusion body myositis (IBM) is a poorly understood and refractory autoimmune muscle disease. Though widely believed to have no significant humoral autoimmunity, we sought to identify novel autoantibodies with high specificity for this disease. Methodology/Principal Findings: Plasma autoantibodies from 65 people, including 25 with IBM, were analyzed by immunoblots against normal human muscle. Thirteen of 25 (52%) IBM patient samples recognized an approximately 43 kDa muscle protein. No other disease (N = 25) or healthy volunteer (N = 15) samples recognized this protein. Conclusions: Circulating antibodies against a 43-kDa muscle autoantigen may lead to the discovery of a novel biomarker for IBM. Its high specificity for IBM among patients with autoimmune myopathies furthermore suggests a relationship to disease pathogenesis.
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页数：3
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