A model of hippocampal memory encoding and retrieval: GABAergic control of synaptic plasticity

被引:270
|
作者
Paulsen, O
Moser, EI
机构
[1] Univ Oxford, Dept Pharmacol, MRC, Anat Neuropharmacol Unit, Oxford OX1 3TH, England
[2] Norwegian Univ Sci & Technol, Dept Psychol, N-7034 Trondheim, Norway
基金
英国惠康基金;
关键词
D O I
10.1016/S0166-2236(97)01205-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The current view of the role of GABAergic interneurones in cortical-network function has shifted from one of merely dampening neuronal activity to that of an active role in information processing. In this review, we explore a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditions for modifications of synaptic weights during hippocampus-dependent memory processes. We argue that knowledge of spatiotemporal activity-patterns in distinct classes of interneurone is essential to understanding the cellular mechanisms underlying learning and memory.
引用
收藏
页码:273 / 278
页数:6
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