Refined Identification of Neutralization-Resistant HIV-1 CRF02_AG Viruses

被引：6

作者：

Jacob, Rajesh Abraham ^{[1
,2
]}

Abrahams, Fatima ^{[1
]}

Tongo, Marcel ^{[3
,4
]}

Schomaker, Michael ^{[5
]}

Roux, Paul ^{[6
,7
]}

Ngole, Eitel Mpoudi ^{[4
]}

Burgers, Wendy A. ^{[3
,8
]}

Dorfman, Jeffrey R. ^{[1
,2
]}

机构：

[1] Int Ctr Genet Engn & Biotechnol, Cape Town, South Africa

[2] Univ Cape Town, Dept Clin Lab Sci, Div Immunol, ZA-7700 Rondebosch, South Africa

[3] Univ Cape Town, Dept Clin Lab Sci, Div Med Virol, ZA-7700 Rondebosch, South Africa

[4] Ctr Rech Malad Emergentes & Reemergentes, Yaounde, Cameroon

[5] Univ Cape Town, Ctr Infect Dis Epidemiol & Res, ZA-7700 Rondebosch, South Africa

[6] Univ Cape Town, Sch Child & Adolescent Hlth, ZA-7700 Rondebosch, South Africa

[7] Groote Schuur Hosp, ZA-7925 Cape Town, South Africa

[8] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7700 Rondebosch, South Africa

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 14期

关键词：

HUMAN MONOCLONAL-ANTIBODY; TYPE-1; INFECTION; ENV CLONES; PASSIVE-IMMUNIZATION; ENVELOPE VARIANTS; EARLY SUBTYPE; PROTECTION; GLYCOPROTEIN; TRANSMISSION; CHALLENGE;

D O I：

10.1128/JVI.00804-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied neutralization of CRF02_AG HIV-1-infected plasma samples. In contrast to previous reports, these samples neutralized CRF02_AG viruses better than other viruses. This included six of eight CRF02_AG viruses previously designated resistant (tier 2/3 or 3). Only viruses 253-11 and 278-50 remained highly resistant, but they were sensitive to membrane-proximal external region (MPER)-specific monoclonal antibodies, suggesting neutralization targets for even these viruses. We propose using high-neutralizing-within-subtype samples for evaluation of neutralization resistance of viruses.

引用

页码：7699 / 7703

页数：5

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