Insulin resistance in oligomenorrheic infertile women with non-polycystic ovary syndrome

Objective: To determine whether infertile oligomenorrheic women are insulin resistant, using an oral glucose tolerance test (OGTT). Design: Retrospective study. Setting: National Center for Child Health and Development. Patient(s): One hundred twenty-seven infertile women with oligomenorrhea (oligornenorrheal group) and 177 infertile eumenorrheic women (normal menstrual group) were recruited. Intervention(S): All women underwent an OGTT (75 g glucose). Main Outcome Measure(S): A homeostasis model assessment of insulin resistance (BOMA-IR), area under the curve (AUC) of insulin after the glucose load, and plasma insulin level at 120 minutes after glucose loading (rRl 120) were used as an index of insulin resistance. Result(s): The prevalence of insulin resistance (HOMA-IR >_ 1.73) among oligomenorrheic women was 23.8%, which was significantly higher than that Of eLIMCnorrheic women, at 14.1 %. The glucose AUCs (mean SE) in the oligomenorrheal group (13,609 259 mg/rr n/dl_) were similar to those for the normal menstrual groups (13,054 196 mg/min/dL), but the insulin AUCs of the oligomenortheal group (5333 376 mU - min/L) were significantly higher than those of the normal menstrual groups (4517 266 mU - min/Q. Conclusion(S): The prevalence of insulin resistance assessed using an OGTT was significantly higher among infertile oligomenorrheic women with non-polycystic ovary syndrome than it was among women with normal menstrual cycles.