Stem Cell Transplantation and Cell-Free Treatment for Periodontal Regeneration

被引：22
|
作者：
Iwasaki, Kengo [1 ]
Peng, Yihao [2 ]
Kanda, Ryuhei [1 ]
Umeda, Makoto [2 ]
Ishikawa, Isao [3 ]
机构：
[1] Osaka Dent Univ, Inst Dent Res, Osaka 5731121, Japan
[2] Osaka Dent Univ, Dept Periodontol, Osaka 5731121, Japan
[3] Tokyo Womens Med Univ, Inst Adv Biomed Engn & Sci, Tokyo 1628666, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期
关键词：
periodontal disease; regeneration; cell transplantation; conditioned medium; exosome; TISSUE REGENERATION; ALVEOLAR BONE; FURCATION DEFECTS; DECIDUOUS TEETH; LIGAMENT CELLS; IN-VIVO; SHEETS; IMPLANTATION; CEMENTUM; REPAIR;
D O I：
10.3390/ijms23031011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Increasing attention has been paid to cell-based medicines. Many in vivo and in vitro studies have demonstrated the efficacy of stem cell transplantation for the regeneration of periodontal tissues over the past 20 years. Although positive evidence has accumulated regarding periodontal regeneration using stem cells, the exact mechanism of tissue regeneration is still largely unknown. This review outlines the practicality and emerging problems of stem cell transplantation therapy for periodontal regeneration. In addition, possible solutions to these problems and cell-free treatment are discussed.
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页数：14
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