Chiral squaramide-catalyzed highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes

被引：77
|
作者：
Yang, Wen [1 ]
Du, Da-Ming [1 ]
机构：
[1] Beijing Inst Technol, Sch Chem Engn & Environm, Beijing 100081, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 47期
基金：
中国国家自然科学基金;
关键词：
CONJUGATE ADDITION; ORGANOCATALYSIS; DERIVATIVES;
D O I：
10.1039/c1cc15946a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient highly diastereo- and enantioselective direct Michael addition of nitroalkanes to nitroalkenes catalyzed by chiral squaramide catalyst has been developed. This organocatalytic reaction with a low catalyst loading (2 mol%) proceeded well to afford synthetically useful 1,3-dinitro compounds in high yields with high diastereoselectivities (up to 95:5 dr) and excellent enantioselectivities (up to 97% ee).
引用
收藏
页码：12706 / 12708
页数：3
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