Cell Adhesion Molecules and Their Involvement in Autism Spectrum Disorder

被引:33
|
作者
Ye, Haihong [2 ]
Liu, Jianghong [2 ]
Wu, Jane Y. [1 ]
机构
[1] Northwestern Univ, Dept Neurol, Feinberg Sch Med, Ctr Genet Med,Lurie Canc Ctr, Chicago, IL 60611 USA
[2] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China
基金
美国国家科学基金会;
关键词
Autism spectrum disorder; Cell adhesion molecules; Neural development; Neurexins; COPY NUMBER VARIATION; SEROTONIN TRANSPORTER; ASSOCIATION ANALYSIS; CYTOGENETIC ANALYSIS; VARIABLE PHENOTYPE; MENTAL-RETARDATION; RISK LOCI; GENE; DELETION; MUTATION;
D O I
10.1159/000322543
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by abnormalities in social interaction, language development and behavior. Recent genetic studies demonstrate that alterations in synaptic genes including those encoding cell adhesion molecules and their interaction partners play important roles in the pathogenesis of ASD. Systematic analyses of different cell adhesion molecule genes will help elucidate their normal functions and regulatory mechanisms in the establishment and maintenance of normal neural circuits and uncover genetic aberrations contributing to ASD. Copyright (C) 2011 S. Karger AG, Basel
引用
收藏
页码:62 / 71
页数:10
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