Molecularly imprinted polymer with bi-functional monomers of calix arene derivative and acrylamide for selective recognition of hydantoin-based compounds

Using calix [4] arene derivative and acrylamide (AM) as the bi-functional monomers and 5-benzylhydantoin(R-BZH) as a template, a molecularly imprinted polymer was prepared to recognize hydantoin-based compounds selectively. The results of equilibrium binding experiments indicate that the selectivity of the MIP, which is synthesized with a single functional monomer calix [4] arene derivative or acrylamide is poor; while the selectivity of another MIP, which is synthesized with two functional monomers (both calix [4] arene derivative and AM), showed higher and better selective recognition abilities for R-BZH. It was entirely possible to separate and enrich R-BZH from hydantoin-based compounds by molecularly imprinting technique.