Spectrophotometric determination of cefaclor in pharmaceutical preparations

A simple spectrophotometric method is proposed for the determination of cefaclor, The method involves alkaline hydrolysis of the drug in ammonia buffer solution at pH 10 to yield diketopiperazine-2,5-dione derivative and subsequent measurement at 340 nm, Beer's law is obeyed in the concentration range 1.8 - 55 mu g/mL, The proposed method was successfully applied to the determination of cefaclor in pharmaceutical formulations.