Effect of Remifentanil on Arterial Oxygenation During One-lung Ventilation

被引：10

作者：

Ryu, C. G. ^{[2
]}

Min, S. W. ^{[1
]}

Kim, J. H. ^{[2
]}

Han, S. H. ^{[2
]}

Do, S. H. ^{[2
]}

Kim, C. S. ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Boramae Med Ctr, Dept Anaesthesiol & Pain Med, Seoul 156707, South Korea

[2] Seoul Natl Univ, Bundang Hosp, Dept Anaesthesiol & Pain Med, Songnam, South Korea

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2010年 / 38卷 / 05期

关键词：

REMIFENTANIL; PROPOFOL; INTRAVENOUS ANAESTHESIA; ARTERIAL OXYGENATION; ONE-LUNG VENTILATION; LUNG RESECTION SURGERY; HYPOXIC PULMONARY VASOCONSTRICTION; SHUNT FRACTION; SEVOFLURANE; ISOFLURANE; DESFLURANE; ANESTHESIA; PROPOFOL; CAT;

D O I：

10.1177/147323001003800520

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study was designed to assess the dose-related effects of remifentanil on arterial oxygenation during one-lung ventilation (OLV) under total intravenous anaesthesia with propofol. A total of 104 patients scheduled for elective lung resection surgery requiring OLV were randomly assigned to one of four groups with a target effect-site concentration (Ce) of remifentanil of 0.5, 1, 2 or 4 ng/ml. Patients were anaesthetized with propofol and remifentanil in 100% oxygen. Arterial blood gas analysis was performed after 15 min of two-lung ventilation (TLV15, baseline) and after 15 and 30 min of OLV (OLV15 and OLV30). Mean arterial oxygen tension (PaO2) decreased significantly at OLV15 and OLV30 compared with baseline in all groups, but was comparable in the four groups at each time point, suggesting that remifentanil infusion with a Ce <= 4 ng/ml can be successfully used for anaesthesia with propofol during OLV in lung surgery without any significant changes in PaO2.

引用

页码：1749 / 1758

页数：10

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