Enhanced folate binding of cultured fibroblasts from Alzheimer's disease patients

被引：7

作者：

Cazzaniga, Emanuela ^{[1
]}

Bulbarelli, Alessandra ^{[1
]}

Lonati, Elena ^{[1
]}

Re, Francesca ^{[1
]}

Galimberti, Gloria ^{[2
]}

Gatti, Elena ^{[1
]}

Pitto, Marina ^{[1
]}

Ferrarese, Carlo ^{[2
,3
,4
]}

Masserini, Massimo ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dept Expt Med, I-20052 Monza, MI, Italy

[2] Univ Milano Bicocca, Dept Neurosci & Biomed Technol, I-20052 Monza, MI, Italy

[3] Osped San Gerardo, Dept Neurol, I-20052 Monza, MI, Italy

[4] Sci Inst E Medea, I-23842 Bosisio Parini, LC, Italy

来源：

NEUROSCIENCE LETTERS | 2008年 / 436卷 / 03期

关键词：

Alzheimer's disease; folate; fibroblasts; folate carrier; folate receptor alpha;

D O I：

10.1016/j.neulet.2008.03.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We compared the levels of serum folate from Alzheimer's disease (AD) patients and from age-matched healthy subjects and used primary cultures of fibroblasts, obtained from the two groups, to assess possible differences in their ability to bind folate. The results show that the levels of circulating folate are significantly (p < 0.01; n = 30) lower in AD patients than in controls (4.91 +/- 2.44 and 7.56 +/- 2.5 ng/mL, respectively). Moreover, the folate binding of AD fibroblasts is significantly (p < 0.01; n = 8) higher (2-4-fold) with respect to controls. RT-PCR experiments suggest that the higher folate binding could be due to an enhanced expression in AD fibroblasts of folate receptor U. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：317 / 320

页数：4

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