Evaluation of Ovarian Reserve by Measurement of the Serum Levels of Anti-Mullerian Hormone and Follicle-Stimulating Hormone in Intracytoplasmic Sperm Injection Cycles

Background: It is important to evaluate ovarian reserves prior to intracytoplasmic sperm injection (ICSI) treatment. The aim of this study is to determine the accuracy of anti-mullerian hormone (AMH) as a marker for ovarian reserve and to compare it with day-3 serum follicle-stimulating hormone (FSH) levels. Materials and Methods: In this analytic, corss-sectional study, sequential sampling was done on 70 infertile women who underwent ICSI treatment at Imam Khomeini Hospital, Ahvaz, Iran. Initially, 5cc of venous blood was drawn from each patient to measure serum AMH and FSH levels on the day-3 cycle. Patients were divided into two subgroups according to the numbers of oocytes retrieved. Patients were classified as good responders if there were four or more oocytes retrieved, whereas patients with less than four oocytes were poor responders. Results: The basal AMH level correlated with the number of oocytes retrieved (linear Pearson correlation coefficient=0.599), however the basal FSH level had a weakly reverse correlation (correlation coefficient = -0.11). AMH levels had a sensitivity of 85% and specificity of 61.5%, with a cutoff value equal to 2.3 ng/ml which was higher than FSH. Conclusion: AMH serum levels are good predictors of ovarian reserve in comparison with FSH.