Tandem Facial Amphiphiles for Membrane Protein Stabilization

被引：80
|
作者：
Chae, Pil Seok [1 ]
Gotfryd, Kamil [2 ]
Pacyna, Jennifer [3 ]
Miercke, Larry J. W. [4 ]
Rasmussen, Soren G. F. [5 ]
Robbins, Rebecca A. [4 ]
Rana, Rohini R. [3 ]
Loland, Claus J. [2 ]
Kobilka, Brian [5 ]
Stroud, Robert [4 ]
Byrne, Bernadette [3 ]
Gether, Ulrik [2 ]
Gellman, Samuel H. [1 ]
机构：
[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
[2] Univ Copenhagen, Dept Neurosci & Pharmacol, Fac Hlth Sci, DK-2200 Copenhagen, Denmark
[3] Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
[4] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA
[5] Stanford Univ, Stanford, CA 94305 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 47期
关键词：
DETERGENTS; STABILITY; BINDING;
D O I：
10.1021/ja1072959
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe a new type of synthetic amphiphile that is intended to support biochemical characterization of intrinsic membrane proteins. Members of this new family displayed favorable behavior with four of five membrane proteins tested, and these amphiphiles formed relatively small micelles.
引用
收藏
页码：16750 / 16752
页数：3
相关论文
共 50 条
  • [1] Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy
    Das, Manabendra
    Du, Yang
    Mortensen, Jonas S.
    Hariharan, Parameswaran
    Lee, Hyun Sung
    Byrne, Bernadette
    Loland, Claus J.
    Guan, Lan
    Kobilka, Brian K.
    Chae, Pil Seok
    CHEMBIOCHEM, 2018, 19 (20) : 2225 - 2232
  • [2] Tandem Facial Amphiphiles for Membrane Protein Stabilization (vol 132, pg 16750, 2010)
    Chae, Pil Seok
    Gotfryd, Kamil
    Pacyna, Jennifer
    Miercke, Larry J. W.
    Rasmussen, Soren G. F.
    Robbins, Rebecca A.
    Rana, Rohini R.
    Loland, Claus J.
    Kobilka, Brian
    Stroud, Robert
    Byrne, Bernadette
    Gether, Ulrik
    Gellman, Samuel H.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2013, 135 (34) : 12922 - 12922
  • [3] Designing facial amphiphiles for the stabilization of integral membrane proteins
    Zhang, Qinghai
    Ma, Xingquan
    Ward, Andrew
    Hong, Wen-Xu
    Jaakola, Veli-Pekka
    Stevens, Raymond C.
    Finn, M. G.
    Chang, Geoffrey
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (37) : 7023 - 7025
  • [4] Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins
    Lee, Sung Chang
    Bennett, Brad C.
    Hong, Wen-Xu
    Fu, Yu
    Baker, Kent A.
    Marcoux, Julien
    Robinson, Carol V.
    Ward, Andrew B.
    Halpert, James R.
    Stevens, Raymond C.
    Stout, Charles David
    Yeager, Mark J.
    Zhang, Qinghai
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (13) : E1203 - E1211
  • [5] Accessible Steroid-based Amphiphiles for Membrane Protein Solubilization and Stabilization
    Chae, Pil Seok
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2015, 36 (08) : 1955 - 1956
  • [6] BIOL 66-New tripod amphiphiles for membrane protein solubilization and stabilization
    Chae, Pil Seok
    Wander, Marc J.
    Bowling, Aaron P.
    Laible, Philip D.
    Gellman, Samuel H.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
  • [7] Improved Glucose-Neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Solubilization and Stabilization
    Cho, Kyung Ho
    Bae, Hyoung Eun
    Das, Manabendra
    Gellman, Samuel H.
    Chae, Pil Seok
    CHEMISTRY-AN ASIAN JOURNAL, 2014, 9 (02) : 632 - 638
  • [8] 1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization
    Ghani, Lubna
    Munk, Chastine F.
    Zhang, Xiang
    Katsube, Satoshi
    Du, Yan
    Cecchetti, Cristina
    Huang, Weijiao
    Bae, Hyoung Eun
    Saouros, Savvas
    Ehsan, Muhammad
    Guan, Lan
    Liu, Xiangyu
    Loland, Claus J.
    Kobilka, Brian K.
    Byrne, Bernadette
    Chae, Pil Seok
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2019, 141 (50) : 19677 - 19687
  • [9] Glycotripod amphiphiles for solubilization and stabilization of a membrane-protein superassembly: Importance of branching in the hydrophilic portion
    Chae, Pil S.
    Wander, Marc J.
    Bowling, Aaron P.
    Laible, Philip D.
    Gellman, Samuel H.
    CHEMBIOCHEM, 2008, 9 (11) : 1706 - 1709
  • [10] Tripod amphiphiles for membrane protein manipulation
    Chae, Pil Seok
    Laible, Philip D.
    Gellman, Samuel H.
    MOLECULAR BIOSYSTEMS, 2010, 6 (01) : 89 - 94
12345