Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family

被引：174
|
作者：
de Groot, RP [1 ]
Coffer, PJ [1 ]
Koenderman, L [1 ]
机构：
[1] Univ Utrecht Hosp, Dept Pulm Dis, NL-3508 GA Utrecht, Netherlands
来源：
CELLULAR SIGNALLING | 1998年 / 10卷 / 09期
关键词：
IL-3/IL-5/GM-CSF; apoptosis; signal transduction; hematopoiesis; JAK/STAT; kinases;
D O I：
10.1016/S0898-6568(98)00023-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The receptors for the Il-3/IL-5/GM-CSF cytokine family are composed of a heterodimeric complex of a cytokine-specific alpha chain and a common beta chain (beta c). Binding of IL-3/IL-5/GM-CSF to their respective receptors rapidly induces activation of multiple intracellular signalling pathways, including the Ras-Raf-ERK, the JAK/STAT, the phosphatidylinositol 3-kinase PKB, and the JNK/SAPK and p38 signalling pathways. This re view focuses on recent advancements in understanding how these different signalling pathways are activated by IL-3/IL-5/GM-CSF receptors, and how the individual pathways contribute to the pleiotropic effects of IL-3/IL-5/GM-CSF on their target cells, including proliferation, differentiation, survival, and effector functions. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：619 / 628
页数：10
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