Association between plasma neurofilament light chain levels and cognitive function in patients with Parkinson's disease

被引：15

作者：

Zhu, Yongyun ^{[1
]}

Yang, Baiyuan ^{[2
]}

Wang, Fang ^{[1
]}

Liu, Bin ^{[1
]}

Li, Kelu ^{[1
]}

Yin, Kangfu ^{[1
]}

Yin, Wei Fang ^{[1
]}

Zhou, Chuanbin ^{[1
]}

Tian, Sijia ^{[3
]}

Ren, Hui ^{[1
]}

Pang, Ailan ^{[4
]}

Yang, Xinglong ^{[1
]}

机构：

[1] Kunming Med Univ, Affiliated Hosp 1, Dept Geriatr Neurol, Kunming 650032, Yunnan, Peoples R China

[2] Seventh Peoples Hosp Chengdu, Dept Neurol, Chengdu 690041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Sichuan, Peoples R China

[4] Kunming Med Univ, Affiliated Hosp 1, Dept Neurol, Kunming 650032, Yunnan, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 358卷

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; Cognitive impairment; dysfunction; disease progress; plasma neurofilament light chain; SLEEP BEHAVIOR DISORDER; NEURODEGENERATION; IMPAIRMENT; RBD; BIOMARKER; SEVERITY; SYMPTOMS; DEMENTIA; DECLINE; ATROPHY;

D O I：

10.1016/j.jneuroim.2021.577662

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study investigated the potential association between levels of plasma neurofilament light chain (NfL) and cognitive function in patients suffering from Parkinson's disease (PD) in P.R. China.We collected a total of 168 participants (130 PD patients and 38 healthy controls),and evaluated the relationship of plasma NfL levels with cognitive dysfunction in PD patients. Our results shown that plasma NfL levels increased with an increase in cognitive impairment across the three groups of PD patients: PD with normal cognition (PD-NC), 17.9 +/- 8.9 pg/ ml; PD with mild cognitive impairment (PD-MCI),21.9 +/- 10.3 pg/ml; and PD dementia (PDD), 35.7 +/- 21.7 pg/ ml. Higher MMSE scores were associated with lower plasma NfL levels (r = -0.49, 95% CI -0.61 to -0.34, p < 0.0001). Our results associating plasma NfL levels with cognitive dysfunction in PD are consistent with previous studies carried out in several countries/district, based on our meta-analysis.

引用

页数：8

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