Effectively Targeting Burkitt Lymphoma By Anti-CD20 Chimeric Antigen Receptor (CAR) Modified Expanded Natural Killer Cells Combined with a Histone Deacetylase Inhibitor, Romidepsin in Vitro and In Humanized NSG Mice

被引：2
|
作者：
Chu, Yaya [1 ]
Yahr, Ashlin [1 ]
Ayello, Janet [1 ]
Cairo, Mitchell S. [1 ]
机构：
[1] New York Med Coll, Valhalla, NY 10595 USA
来源：
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2015年 / 21卷 / 02期
关键词：
D O I：
10.1016/j.bbmt.2014.11.216
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
181
引用
收藏
页码：S152 / S153
页数：2
相关论文
共 45 条
  • [1] Effectively Targeting Burkitt Lymphoma By Anti-CD20 Chimeric Antigen Receptor (CAR) Modified Expanded Natural Killer Cells Combined with a Histone Deacetylase Inhibitor, Romidepsin in-Vitro and in Humanized NSG Mice
    Chu, Yaya
    Yahr, Ashlin
    Ayello, Janet
    Cairo, Mitchell S.
    [J]. BLOOD, 2014, 124 (21)
  • [2] Effectively targeting sensitive and resistant Burkitt lymphoma by anti-CD20 chimeric antigen receptor (CAR) modified expanded natural killer (NK) cells combined with a histone deacetylase inhibitor, romidepsin
    Chu, Y.
    Yahr, A.
    Ayello, J.
    Lo, L.
    Katz, J.
    Cairo, M.
    [J]. BONE MARROW TRANSPLANTATION, 2013, 48 : S15 - S15
  • [3] Enhanced in vitro and in vivo targeting of rituximab-sensitive and -resistant Burkitt lymphoma (BL) by anti-CD20 chimeric antigen receptor (CAR)-modified expanded natural killer cells in combination with a histone deacetylase inhibitor, romidepsin
    Chu, Yaya
    Yahr, Ashlin
    Cheng, Bokun
    Hang, Bian
    Ayello, Janet
    Bath, Matthew
    Cairo, Mitchell S.
    [J]. CANCER RESEARCH, 2016, 76
  • [4] Romidepsin alone or in combination with anti-CD20 chimeric antigen receptor expanded natural killer cells targeting Burkitt lymphoma in vitro and in immunodeficient mice
    Chu, Yaya
    Yahr, Ashlin
    Huang, Brian
    Ayello, Janet
    Barth, Matthew
    Cairo, Mitchell S.
    [J]. ONCOIMMUNOLOGY, 2017, 6 (09):
  • [5] Enhanced in-Vitro and in-Vivo Targeting of Rituximab Sensitive and Resistant Burkitt Lymphoma (BL) By Anti-CD20 Chimeric Antigen Receptor (CAR) Modified Expanded Natural Killer Cells in Combination with a Histone Deacetylase Inhibitor, Romidepsin
    Chu, Yaya
    Yahr, Ashlin
    Cheng, Bokun
    Hang, Brian
    Ayello, Janet
    Barth, Matthew
    Cairo, Mitchell S.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2016, 22 (03) : S392 - S392
  • [6] ENHANCED IN-VITRO AND IN-VIVO TARGETING OF RITUXIMAB SENSITIVE AND RESISTANT BURKITT LYMPHOMA (BL) BY ANTI-CD20 CHIMERIC ANTIGEN RECEPTOR (CAR) MODIFIED EXPANDED NATURAL KILLER CELLS IN COMBINATION WITH A HISTONE DEACETYLASE INHIBITOR, ROMIDEPSIN
    Chu, Yaya
    Yahr, Ashlin
    Cheng, Bokun
    Huang, Brian
    Ayello, Janet
    Barth, Matthew
    Cairo, Mitchell S.
    [J]. PEDIATRIC BLOOD & CANCER, 2016, 63 : S96 - S96
  • [7] Enhanced Targeting B Cell Lymphoma/Leukemia (B-L/L) by Anti-CD20 Chimeric Antigen Receptor (CAR) Modified Expanded Natural Killer (NK) Cells Combined with a Histone Deacetylase Inhibitor, Romidepsin
    Chu, Yay
    Yahr, Ashlin
    Lo, Lowrence
    Ayello, Janet
    Katz, Jared
    Cairo, Mitchell S.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2013, 19 (02) : S313 - S314
  • [8] ENHANCED TARGETING PEDIATRIC B CELL LYMPHOMA/LEUKEMIA (B-L/L) BY ANTI-CD20 CHIMERIC ANTIGEN RECEPTOR (CAR) MODIFIED EXPANDED NATURAL KILLER (NK) CELLS COMBINED WITH A HISTONE DEACETYLASE INHIBITOR, ROMIDEPSIN
    Chu, Yaya
    Yahr, Ashlin
    Ayello, Janet
    Lo, Lowrence
    Katz, Jared
    Cairo, Mitchell
    [J]. PEDIATRIC BLOOD & CANCER, 2013, 60 : S97 - S97
  • [9] Anti-CD20 chimeric antigen receptor modified expanded natural killer cells have significant cytotoxicity against poor risk CD20+ Burkitt lymphoma in vitro and in xenografted NSG mice
    Chu, Yaya
    Yahr, Ashlin
    Lee, Fangyu
    Hochberg, Jessica
    Ayello, Janet
    van de Ven, Carmella
    Flower, Allyson
    Barth, Matthew
    Czuczman, Myron
    Cairo, Mitchell S.
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2015, 171 : 44 - 45
  • [10] Therapeutic effects of Romidepsin, a histone deacetylase inhibitor, in combination with anti-C20 chimeric antigen receptor modified expanded natural killer cells against pediatric Burkitt lymphoma (BL)
    Chu, Yaya
    Yahr, Ashlin
    Lee, Fangyu
    Ayello, Janet
    Cairo, Mitchell
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2015, 171 : 82 - 83
12345