Cobalt-Catalyzed Direct C(sp2)-H Alkylation with Unactivated Alkenes

被引：8
|
作者：
Kim, Ye Lim [1 ]
Park, Sun-a [1 ]
Kim, Ju Hyun [1 ]
机构：
[1] Gyeongsang Natl Univ, Inst Res Inst Nat Sci, Dept Chem BK21 Plus, Jinju 52828, South Korea
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 26期
基金：
新加坡国家研究基金会;
关键词：
C-H alkylation; Co(III)-catalyst; Phenylethyl group; Unactivated alkenes; C-H BOND; ACTIVATION; HYDROARYLATION; SELECTIVITY; INDOLES; IRIDIUM; ENABLES; ACCESS; FURANS;
D O I：
10.1002/ejoc.202000565
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient method for Cp*Co-III-catalyzed C(sp(2))-H bond alkylation was developed using 2-aryl pyridines and unactivated alkenes. The reaction proceeded atom-economically with readily available styrene derivatives and an abundant cobalt catalyst. This reaction tolerates a broad range of functional groups, directing groups, styrenes and affords mono-diarylethane products with high linear selectivity. To demonstrate the synthetic utility and the potential application in organic synthesis, a gram-scale reaction and further C-H bond functionalizations of the mono-alkylated product were performed.
引用
收藏
页码：4026 / 4030
页数：5
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