Oxidative C-H/C-H Coupling of Azine and Indole/Pyrrole Nuclei: Palladium Catalysis and Synthesis of Eudistomin U

被引：102

作者：

Yamaguchi, Atsushi D. ^{[1
]}

Mandal, Debashis ^{[1
]}

Yamaguchi, Junichiro ^{[1
]}

Itami, Kenichiro ^{[1
]}

机构：

[1] Nagoya Univ, Dept Chem, Grad Sch Sci, Aichi 4648602, Japan

来源：

CHEMISTRY LETTERS | 2011年 / 40卷 / 06期

关键词：

PYRIDINE-N-OXIDES; DIRECT ARYLATION; BOND ARYLATION; SIMPLE ARENES; HETEROAROMATIC-COMPOUNDS; UNACTIVATED ARENES; SODIUM PERSULFATE; ARYLBORONIC ACIDS; FUNCTIONALIZATION; HETEROCYCLES;

D O I：

10.1246/cl.2011.555

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a palladium-catalyzed C-H/C-H coupling reaction of indoles or pyrroles with azine N-oxides. The reaction proceeds selectively at the C3 position of indoles/pyrroles and the C2 position of azine N-oxides. Furthermore, we have accomplished the synthesis of marine indole alkaloid eudistomin U by utilizing this newly developed C-H/C-H coupling reaction.

引用

页码：555 / 557

页数：3

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