Marine Biopolymer-Based Nanomaterials as a Novel Platform for Theranostic Applications

被引:43
|
作者
Manivasagan, Panchanathan [1 ]
Bharathiraja, Subramaniyan [1 ]
Moorthy, Madhappan Santha [1 ]
Oh, Yun-Ok [1 ]
Seo, Hansu [2 ,3 ]
Oh, Junghwan [1 ,2 ,3 ]
机构
[1] Pukyong Natl Univ, Marine Integrated Bion Res Ctr, Busan 608737, South Korea
[2] Pukyong Natl Univ, Dept Biomed Engn, Busan 608737, South Korea
[3] Pukyong Natl Univ, Ctr Marine Integrated Biotechnol Plus BK21, Busan 608737, South Korea
关键词
Marine biopolymer; nanomaterials; theranostic applications; cancer therapy; near-infrared; POLYSACCHARIDE-BASED NANOMATERIALS; MESOPOROUS SILICA NANOPARTICLES; GLYCOL CHITOSAN NANOPARTICLES; COPPER SULFIDE NANOPARTICLES; SHAPE-CONTROLLED SYNTHESIS; COATED GOLD NANOPARTICLES; PHOTOTHERMAL THERAPY PPTT; IRON-OXIDE NANOPARTICLES; PH-SENSITIVE HYDROGEL; DRUG-DELIVERY;
D O I
10.1080/15583724.2017.1311914
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Marine biopolymer-based nanomaterials are one of the most active research areas in recent decades for theranostic applications. Marine biopolymers are interesting biomaterials for clinical applications because of their good biocompatibility, biodegradability, inexpensiveness, abundance, stability, ease of surface modification, and nontoxic nature. New nanoparticles in development are coated with marine polymers to combine therapeutic and diagnostic (theranostic) applications because of the strongly enhanced absorption and scattering in near-infrared (NIR) regions. In this review, the use of marine biopolymer-based nanomaterials for theranostic applications is evaluated, addressing potential applications in drug delivery, photothermal therapy (PTT), photodynamic therapy (PDT), hyperthermia therapy, photoacoustic imaging (PAI), magnetic resonance imaging (MRI), and computed tomography (CT). In addition, the most recent progress in the biocompatibility of marine biopolymer-based nanomaterials in vitro and in vivo are discussed, along with a promising future scope for the treatment of major life-threatening diseases such as cancer.
引用
收藏
页码:631 / 667
页数:37
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