Antiulcerogenic Activity of Scoparone on HCl/Ethanol-induced Gastritis in Rats

被引：8
|
作者：
Choi, Won Sik [2 ]
Jang, Do Yoen [3 ]
Nam, Seok Woo [2 ]
Park, Byeoung Soo [1 ]
Lee, Hoi-Seon [4 ]
Lee, Sung Eun [1 ]
机构：
[1] Nanotoxtech Inc, Res Stn, Gyeonggi Technopk Technol Dev Ctr, Ansan 426901, South Korea
[2] Soonchunhyang Univ, Dept Biotechnol, Asan 336745, South Korea
[3] Dongbang FTL, Res Stn, Hwasung 445922, South Korea
[4] Chonbuk Natl Univ, Dept Bioenvironm Chem, Jeonju 561756, South Korea
来源：
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2012年 / 55卷 / 02期
关键词：
Artemisia capillaries; Hericium erinaceum gastritis; rat; scoparone; HERICIUM-ERINACEUM; ARTEMISIA-IWAYOMOGI; EXTRACT; CELLS; PROLIFERATION; CONSTITUENT; DERIVATIVES; ACTIVATION; LESIONS; MICE;
D O I：
10.1007/s13765-012-1023-y
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Protective effect of ethanol extract from Hericium erinaceus cultivated with Artemisia capillaries (HEAC) on gastric mucosal damage induced by 0.15 M HCl in ethanol in rats was evaluated. HEAC showed higher potent protective effect on gastritis with effective dose 50 (ED50) value of 22.6 mg/kg compared those of selbex and stillen at 46.5 and 44.2 mg/kg, respectively, the presently used medicines for treating gastritis. ichloromethane fraction showed a dose-dependent protective effect on gastritis with ED50 value of 18.1 mg/kg. The biologically active component of dichloromethane fraction derived from HEAC ethanolic extract was characterized by spectroscopic analysis as scoparone with protective rate of 93% and ED50 value of 4.2 mg/kg on gastritis. Taken together, administration of HEAC and scoparone provided protective effect on the gastric lesion induced by ethanol-HCl and may therefore be a promising drug for treatment of gastritis and gastric ulcer.
引用
收藏
页码：159 / 163
页数：5
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