The purpose of this review is to understand the risk and protective factors that are associated with substance use among Asian American youth. Using the Bronfenbrenner's (1994) ecological systems theory, we examine how individual characteristics (age, gender, psychopathology, genetics, and ethnic differences), micro(family and peers), meso-/exo- (relations between family and peers, cultural norms, and economic stress), macro- (academic achievement and cultural influences), and chrono-systems (acculturation) level factors influence or inhibit substance use among Asian American youth. In addition, this review highlights major implications for practice and policy to prevent substance misuse and to improve outcomes for substance abusing Asian American youth. (C) 2010 Elsevier Ltd. All rights reserved.