In the past sicca syndromes were attributed to destruction of glandular tissue. It is now thought that cytokines, autoantibodies, and parasympathetic nervous system dysfunction all have an important role in the xerostomia and xerophthalmia in Sjogren's syndrome.
机构:
Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England
Davies, Kristen
Ng, Wan-Fai
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Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England
Newcastle Univ, Natl Inst Hlth Res NIHR, Newcastle Biomed Res Ctr, Newcastle Upon Tyne, England
Newcastle Upon Tyne Hosp Natl Hlth Serv NHS Fdn T, Newcastle Upon Tyne, Tyne & Wear, EnglandNewcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England