Measuring the cone contribution to the ERG b-wave to assess function and predict anatomical rescue in RCS rats

被引：15

作者：

Pinilla, I ^{[1
]}

Lund, RD ^{[1
]}

Lu, B ^{[1
]}

Sauvé, Y ^{[1
]}

机构：

[1] Univ Utah, Moran Eye Ctr Ophthalmol & Visual Sci, Salt Lake City, UT 84132 USA

来源：

VISION RESEARCH | 2005年 / 45卷 / 05期

关键词：

RCS rat; retinal degeneration; cone; cell based therapy; ERG double flash; pigmented Royal College of Surgeons rat; rdy(+)-p(+);

D O I：

10.1016/j.visres.2004.09.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Subretinal injections of human retinal pigment epithelial (RPE) cells early in the course of retinal degeneration in Royal College of Surgeons (RCS) rats can rescue photoreceptors. Fourteen injected animals were studied using a double flash electroretinogram (ERG): 10 were examined longitudinally and four terminally with immunohistochemistry. The proportion of cone contribution to the ERG b-wave rather than the absolute size of isolated cone response proved to be a reliable indicator of function over time and a predictor of the proportion of cones identified anatomically in the area of optimal photoreceptor rescue. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：635 / 641

页数：7

共 19 条

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Sauve, Y
Pinilla, I
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2004, 45 : U573 - U573
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Pinilla, I
Lund, RD
Sauvé, Y
VISION RESEARCH, 2004, 44 (21) : 2467 - 2474
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VISION RESEARCH, 2006, 46 (22) : 3941 - 3948
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VISION RESEARCH, 1992, 32 (03) : 425 - 432
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EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, : 228 - 228
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2000, 41 (04) : S497 - S497
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INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2000, 41 (04) : S497 - S497
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