MicroRNAs: new players in IBD

被引：218
|
作者：
Kalla, R. [1 ]
Ventham, N. T. [1 ]
Kennedy, N. A. [1 ]
Quintana, J. F. [2 ]
Nimmo, E. R. [1 ]
Buck, A. H. [2 ]
Satsangi, J. [1 ]
机构：
[1] Western Gen Hosp, Gastrointestinal Unit, Ctr Mol Med, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland
[2] Univ Edinburgh, Ashworth Labs, Ctr Immun Infect & Evolut, Edinburgh, Midlothian, Scotland
来源：
GUT | 2015年 / 64卷 / 03期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; NUCLEAR EXPORT; EPITHELIAL BARRIER; NETWORK MOTIFS; KAPPA-B; MIR-17-SIMILAR-TO-92; FAMILY; CIRCULATING MICRORNAS; WIDE ASSOCIATION; IMMUNE-RESPONSES;
D O I：
10.1136/gutjnl-2014-307891
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.
引用
收藏
页码：504 / 517
页数：14
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