DNA Methylation and Histone Modification in Dental-derived Mesenchymal Stem Cells

被引：3
|
作者：
Zeng, Biyun [1 ,2 ,3 ,4 ]
Liu, Gui [1 ,2 ,3 ,4 ]
Huang, Junhui [1 ,2 ,3 ,4 ]
机构：
[1] Cent South Univ, Xiangya Stomatol Hosp, Dept Oral Pathol, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Sch Stomatol, Changsha, Hunan, Peoples R China
[3] Cent South Univ, Hunan Key Lab Oral Hlth Res, Changsha, Hunan, Peoples R China
[4] Cent South Univ, Hunan 3D Printing Engn Res Ctr Oral Care, Changsha, Hunan, Peoples R China
来源：
STEM CELL REVIEWS AND REPORTS | 2022年 / 18卷 / 08期
关键词：
Dental-derived mesenchymal stem cells; Epigenetic regulation; DNA methylation; Histone methylation; Histone acetylation; CHONDROGENIC DIFFERENTIATION POTENTIALS; INDUCED INFLAMMATORY RESPONSE; OSTEOGENIC DIFFERENTIATION; ODONTOGENIC DIFFERENTIATION; ODONTOBLASTIC DIFFERENTIATION; DEACETYLASE INHIBITION; INDUCED SUPPRESSION; PULP CELLS; SIRTUIN; EXPRESSION;
D O I：
10.1007/s12015-022-10413-0
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs (ncRNAs), is essential for the regulation of multiple cellular processes. Dental-derived mesenchymal stem cells (DMSCs), a kind of multipotent cells derived from dental tissues, are impactful in regenerative medicine. Recent studies have shown that epigenetic regulation plays a major role in DMSCs. Therefore, exploring how epigenetic regulation is involved in DMSCs may be of guiding significance for tissue repair and regeneration or for exploring more effective treatments. A number of research of ncRNAs in DMSCs have been reported. However, little is known about the roles of DNA methylation and histone modifications in DMSCs. In this review, we summarize the important roles of DNA methylation and histone modifications of the fate of DMSCs.
引用
收藏
页码：2797 / 2816
页数：20
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