Linear hypothesis testing in high-dimensional one-way MANOVA: a new normal reference approach

For the general linear hypothesis testing problem for high-dimensional data, several interesting tests have been proposed in the literature. Most of them have imposed strong assumptions on the underlying covariance matrix so that their test statistics under the null hypothesis are asymptotically normally distributed. In practice, however, these strong assumptions may not be satisfied or hardly be checked so that these tests are often applied blindly in real data analysis. Their empirical sizes may then be much larger or smaller than the nominal size. For these tests, this is a size control problem which cannot be overcome via purely increasing the sample size to infinity. To overcome this difficulty, in this paper, a new normal-reference test using the centralized L-2-norm based test statistic with three cumulant matched chi-square approximation is proposed and studied. Some theoretical discussion and two simulation studies demonstrate that in terms of size control, the new normal-reference test performs very well regardless of if the high-dimensional data are nearly uncorrelated, moderately correlated, or highly correlated and it outperforms two existing competitors substantially. Two real high-dimensional data examples motivate and illustrate the new normal-reference test.