Expression and function of tumour necrosis factor-α-converting enzyme in the central nervous system

被引：22
|
作者：
Moro, MA [1 ]
Hurtado, O [1 ]
Cárdenas, A [1 ]
Romera, C [1 ]
Madrigal, JLM [1 ]
Fernández-Tomé, P [1 ]
Leza, JC [1 ]
Lorenzo, P [1 ]
Lizasoain, I [1 ]
机构：
[1] Univ Complutense Madrid, Fac Med, Dept Farmacol, ES-28040 Madrid, Spain
来源：
NEUROSIGNALS | 2003年 / 12卷 / 02期
关键词：
metalloproteases; neuroinflammation; stroke; ischemic tolerance; neuroprotection;
D O I：
10.1159/000071814
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumour necrosis factor-alpha (TNF-alpha)-converting enzyme (TACE/ADAM17) is a membrane protein belonging to the ADAM (a disintegrin and a metalloprotease) family able to cleave various membrane proteins, including the transmembrane form of TNF-alpha at its physiological processing site. Being an ADAM, TACE may mediate not only proteolysis but also adhesive interactions; however, the role of the disintegrin domain of TACE has not been studied. In the central nervous system (CNS), little is known about the physiological role of TACE, but some important pathophysiological functions have been reported recently, with both neurotoxic and neuroprotective repercussions. This article discusses and reviews the main contributions to this field of investigation addressing the expression and function of TACE in the CNS. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码：53 / 58
页数：6
相关论文
共 50 条
  • [1] EXPRESSION OF TUMOUR NECROSIS FACTOR-α CONVERTING ENZYME AND TUMOUR NECROSIS FACTOR-α IN RATS WITH ALCOHOLIC CARDIOMYOPATHY
    Li Jianqiang
    Li Weimin
    Li Yue
    Zhao Jiyi
    Kong Yihui
    Guo Hong
    Xue Jingyi
    Sheng Li
    Gong Yongtai
    Xue Hongjie
    HEART, 2010, 96 : A49 - A50
  • [2] Overexpression of tumour necrosis factor-α-converting enzyme in psoriasis
    Kawaguchi, M
    Mitsuhashi, Y
    Kondo, S
    BRITISH JOURNAL OF DERMATOLOGY, 2005, 152 (05) : 915 - 919
  • [3] Tumor necrosis factor-α-converting enzyme is expressed in the inflamed peripheral nervous system
    Kurz, M
    Pischel, H
    Hartung, HP
    Kieseier, BC
    JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 2005, 10 (03) : 311 - 318
  • [4] Tumour necrosis factor-α stimulates expression of TNF-α converting enzyme in endothelial cells
    Bzowska, M
    Jura, N
    Lassak, A
    Black, RA
    Bereta, J
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2004, 271 (13): : 2808 - 2820
  • [5] Localization of tumour necrosis factor-α converting enzyme in normal human skin
    Kawaguchi, M
    Mitsuhashi, Y
    Kondo, S
    CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2004, 29 (02) : 185 - 187
  • [6] Expression and localization of tumour necrosis factor-α and its converting enzyme in human abdominal aortic aneurysm
    Satoh, H
    Nakamura, M
    Satoh, M
    Nakajima, T
    Izumoto, H
    Maesawa, C
    Kawazoe, K
    Masuda, T
    Hiramori, K
    CLINICAL SCIENCE, 2004, 106 (03) : 301 - 306
  • [7] Myocardial expression of tumor necrosis factor-α and tumor necrosis factor-α converting enzyme in human myocarditis
    Satoh, M
    Nakamura, M
    Satoh, H
    Segawa, I
    Masuda, T
    Hiramori, K
    CIRCULATION, 1999, 100 (18) : 381 - 381
  • [8] Tumor necrosis factor-α converting enzyme
    Black, RA
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2002, 34 (01): : 1 - 5
  • [9] Myocardial expression of tumor necrosis factor-α converting enzyme and tumor necrosis factor-α in human dilated cardiomyopathy
    Saitoh, H
    Satoh, M
    Nakamura, M
    Satoh, H
    Segawa, I
    Tashiro, A
    Hiramori, K
    CIRCULATION, 1998, 98 (17) : 853 - 853
  • [10] Effects of biological drug adalimumab on tumour necrosis factor-α-converting enzyme activation
    Lisi, Sabrina
    Sisto, Margherita
    IMMUNOLOGY AND CELL BIOLOGY, 2010, 88 (03): : 297 - 304
12345