Elevated serum lipoprotein(a) as a potential predictor for combined intracranial and extracranial artery stenosis in patients with ischemic stroke

被引:67
|
作者
Kim, B. S. [1 ]
Jung, H. S. [2 ]
Bang, O. Y. [1 ]
Chung, C. S. [1 ]
Lee, K. H. [1 ]
Kim, G. M. [1 ]
机构
[1] Sungkyunkwan Univ, Dept Neurol, Samsung Med Ctr, Sch Med, Seoul 135710, South Korea
[2] Sungkyunkwan Univ, Dept Family Med, Samsung Med Ctr, Sch Med, Seoul 135710, South Korea
关键词
Lipoprotein(a); Risk factors; Atherosclerosis; Carotid stenosis; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; LP(A) LIPOPROTEIN; CAROTID STENOSIS; RISK-FACTORS; ATHEROSCLEROSIS; METAANALYSIS; ASSOCIATION; MORTALITY; OCCLUSION;
D O I
10.1016/j.atherosclerosis.2010.07.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Despite compelling evidence of lipoprotein(a) [Lp(a)] as a risk factor for ischemic stroke, its underlying mechanism remains unclear. Our aim is to investigate whether serum Lp(a) level is associated with the extent and location of cerebral steno-occlusive lesions, and with large artery atherosclerotic (LAA) stroke in Korean patients. Methods: We analyzed data prospectively collected over a 3-year period on consecutive patients with stroke or TIA. Based on an angiographic study, a total of 1012 patients were classified into four subtypes: non-cerebral stenosis (n = 654), intracranial stenosis (n = 198), extracranial carotid stenosis (n = 86), and combined intracranial and extracranial carotid stenosis (n = 74). Independent associations of Lp(a) levels with the extent and location of cerebral stenosis were evaluated, and Lp(a) levels of subtypes by the TOAST criteria were compared. Results: Lp(a) levels of LAA stroke were significantly higher than those of the other four stroke mechanisms. Patients with more advanced intracranial (p = 0.001) and extracranial carotid stenoses (p = 0.001) tended to have higher Lp(a) levels. In multiple regression analysis, the third Lp(a) quartile was the strongest risk factor for isolated intracranial (OR 3.36, 95% CI 1.77-6.37) or extracranial stenosis (OR 4.82, 95% CI 1.96-11.88), whereas the fourth Lp(a) quartile was the most powerful predictor for combined intracranial and extracranial carotid stenosis (OR 4.98, 95% CI 1.92-12.91). Conclusions: Our results indicate that greatly elevated Lp(a) levels are associated with LAA stroke and extensive burden of cervicocerebral steno-occlusive lesions, which might offer indirect evidence of proatherothrombogenic role of Lp(a) in ischemic stroke. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:682 / 688
页数:7
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