Phyllodes Tumor of the Breast With Malignant Melanoma Component: A Case Report

被引：3
|
作者：
Vergine, Marco [1 ]
Guy, Catherine [1 ]
Taylor, Mark R. [1 ]
机构：
[1] Royal Sussex Cty Hosp, Dept Histopathol, Brighton BN2 5BE, E Sussex, England
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2015年 / 23卷 / 06期
关键词：
phyllodes tumor; breast; malignant melanoma; heterologous elements; cancer stem cell; multidirectional divergent differentiation; MELANOCYTIC DIFFERENTIATION; LOCAL RECURRENCE; CARCINOMA; METASTASIS; FEATURES;
D O I：
10.1177/1066896915592018
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Phyllodes tumors of the breast display a wide variation in histological appearance and are classified into benign, borderline, and malignant categories based on a combination of histological parameters. These tumors may include a malignant heterologous component that is believed to originate through a process of multidirectional differentiation from a cancer stem cell. In these cases, the tumor is classified as a malignant phyllodes tumor. Among the heterologous elements that have been described in malignant phyllodes tumors are rhabdomyosarcoma, chondrosarcoma, osteosarcoma, liposarcoma and angiosarcoma. We present the first case of a phyllodes tumor with a malignant melanoma component in the breast of a 71-year-old lady, discussing the clinical implications of this diagnosis.
引用
收藏
页码：483 / 488
页数：6
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