The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing

被引：236
|
作者：
Johnson, Blair Z. [1 ]
Stevenson, Andrew W. [1 ]
Prele, Cecilia M. [1 ,2 ]
Fear, Mark W. [1 ]
Wood, Fiona M. [1 ,3 ]
机构：
[1] Univ Western Australia, Sch Biomed Sci, Crawley, WA 6009, Australia
[2] Univ Western Australia, Inst Resp Hlth, Crawley, WA 6009, Australia
[3] WA Dept Hlth, 189 Royal St, East Perth, WA 6004, Australia
来源：
BIOMEDICINES | 2020年 / 8卷 / 05期
基金：
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词：
IL-6; fibrosis; skin; wounds; ENDOTHELIAL GROWTH-FACTOR; MUSCLE ACTIN EXPRESSION; HYPERTROPHIC SCARS; TRIAMCINOLONE ACETONIDE; SYSTEMIC-SCLEROSIS; DERMAL FIBROBLASTS; DUPUYTRENS-DISEASE; TOPICAL STEROIDS; INTERLEUKIN-6; PATHOGENESIS;
D O I：
10.3390/biomedicines8050101
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-beta feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6 ' s diverse impact on cutaneous wound healing.
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页数：18
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