A case of Beh‡et's disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab

被引：94
|
作者：
Hirano, Toru [1 ]
Ohguro, Nobuyuki [2 ]
Hohki, Satoshi [3 ]
Hagihara, Keisuke [1 ]
Shima, Yoshihito [1 ]
Narazaki, Masashi [1 ]
Ogata, Atsushi [1 ]
Yoshizaki, Kazuyuki [4 ]
Kumanogoh, Atsushi [1 ]
Kishimoto, Tadamitsu [5 ]
Tanaka, Toshio [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Resp Med Allergy & Rheumat Dis, Suita, Osaka 5650871, Japan
[2] Osaka Koseinenkin Hosp, Dept Ophthalmol, Osaka, Japan
[3] Toyama Univ, Dept Ophthalmol, Grad Sch Med & Pharmaceut Sci, Toyama 930, Japan
[4] Osaka Univ, Ctr Adv Sci & Innovat, Suita, Osaka 5650871, Japan
[5] Osaka Univ, Lab Immune Regulat, Grad Sch Frontier Biosci, Suita, Osaka 5650871, Japan
来源：
MODERN RHEUMATOLOGY | 2012年 / 22卷 / 02期
关键词：
Behcet's disease; IL-6; Tocilizumab; GENOME-WIDE ASSOCIATION; BEHCETS-DISEASE; CEREBROSPINAL-FLUID; INTERLEUKIN-6; IL23R-IL12RB2; GENERATION; THERAPY; CELLS; IL10;
D O I：
10.1007/s10165-011-0497-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 47-year-old female patient with Beh double dagger et's disease had been treated with colchicine, prednisolone, cyclosporine A, and infliximab. Because she relapsed, however, treatment with tocilizumab, a humanized anti-interleukin 6 receptor antibody, was started. This treatment suppressed the patient's clinical manifestations, including ocular attacks, for 1 year and improved her visual acuity. This experience indicates that tocilizumab may constitute a therapeutic option for refractory Beh double dagger et's disease.
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页码：298 / 302
页数：5
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