Effects of residual fluorescence on time-resolved signals simulated with the finite element method in biological tissues

被引：1
|
作者：
Kervella, M. [1 ]
Humeau, A. [1 ,2 ]
L'Huillier, J. -P. [3 ,4 ]
机构：
[1] ESAIP, Grp ISAIP, F-49180 St Barthelemy Anjou, France
[2] LISA, F-49000 Angers, France
[3] ENSAM, F-49035 Angers, France
[4] LPMI, F-49035 Angers, France
来源：
IRBM | 2008年 / 29卷 / 01期
关键词：
biological tissues; finite element method; diffusion approximation;
D O I：
10.1016/j.rbmret.2007.11.022
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
A computational model based on finite element method is derived to examine how the simulated time-dependent signals are related to the presence of residual fluorescence in biological media surrounding a fluorescent object. We apply a subtraction technique on recorded data when imperfect uptake of fluorescing agent into the tumor is considered. We show the limits of the subtracting method for low target: background fluorescent absorption contrast by extracting the time to reach the half maximum and analyzing the maximum of the time-resolved signals versus target depth. (C) 2008 Elsevier Masson SAS. Tous droits reserves.
引用
收藏
页码：20 / 24
页数：5
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