Targeted destruction of endogenous K-RAS using an Affinity directed PROtein Missile (AdPROM).

被引：0
|
作者：
Roth, Sascha O. M. [1 ]
Macartney, Thomas J. [1 ]
Konopacka, Agnieszka [2 ]
Queisser, Markus [2 ]
Sapkota, Gopal P. [1 ]
机构：
[1] Univ Dundee, Sch Life Sci, MRC Prot Phosphorylat & Ubiquitylat Unit, Dundee, Scotland
[2] GSK, Stevenage, Herts, England
来源：
MOLECULAR CANCER RESEARCH | 2020年 / 18卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B34
引用
收藏
页码：69 / 69
页数：1
相关论文
共 50 条
  • [1] Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
    Roth, Sascha
    Macartney, Thomas J.
    Konopacka, Agnieszka
    Chan, Kwok-Ho
    Zhou, Houjiang
    Queisser, Markus A.
    Sapkota, Gopal P.
    CELL CHEMICAL BIOLOGY, 2020, 27 (09) : 1151 - +
  • [2] An affinity-directed protein missile system for targeted proteolysis
    Fulcher, Luke J.
    Macartney, Thomas
    Bozatzi, Polyxeni
    Hornberger, Annika
    Rojas-Fernandez, Alejandro
    Sapkota, Gopal P.
    OPEN BIOLOGY, 2016, 6 (10):
  • [3] Endogenous K-ras signaling in erythroid differentiation
    Zhang, Jing
    Lodish, Harvey F.
    CELL CYCLE, 2007, 6 (16) : 1970 - 1973
  • [4] Targeting endogenous proteins for degradation through the affinity-directed protein missile system
    Fulcher, Luke J.
    Hutchinson, Luke D.
    Macartney, Thomas J.
    Turnbull, Craig
    Sapkota, Gopal P.
    OPEN BIOLOGY, 2017, 7 (05):
  • [5] K-Ras protein as a drug target
    Frank McCormick
    Journal of Molecular Medicine, 2016, 94 : 253 - 258
  • [6] K-Ras protein as a drug target
    McCormick, Frank
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2016, 94 (03): : 253 - 258
  • [7] Harnessing Antibody-Mimetic Selectivity for ActivationState-Specific Targeted Degradation of Endogenous K-Ras
    Ferguson, Fleur M.
    ACS CENTRAL SCIENCE, 2021, 7 (02) : 222 - 224
  • [8] Clinical update on K-Ras targeted therapy in gastrointestinal cancers
    Pant, Shubham
    Hubbard, Joleen
    Martinelli, Erika
    Bekaii-Saab, Tanios
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2018, 130 : 78 - 91
  • [9] A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo
    Xin-Yu, Ren
    Zhi-Yong, Liang
    Xiao-Hua, Shi
    Tong-Hua, Liu
    CANCER BIOLOGY & THERAPY, 2008, 7 (10) : 1641 - 1647
  • [10] Protein farnesyltransferase:: H-Ras and K-Rasβ peptide substrate specificity
    Roskoski, R
    Ritchie, P
    Scott, SS
    FASEB JOURNAL, 1997, 11 (09): : A963 - A963
12345