Potassium tert-butoxide promoted regioselective deuteration of pyridines

被引：16

作者：

Li, Yan ^{[1
,2
]}

Zheng, Chenxu ^{[1
,2
]}

Jiang, Zhi-Jiang ^{[1
]}

Tang, Jianbo ^{[1
,3
]}

Tang, Bencan ^{[4
]}

Gao, Zhanghua ^{[1
]}

机构：

[1] NingboTech Univ, Sch Biol & Chem Engn, Ningbo 315100, Peoples R China

[2] Zhejiang Univ, Coll Chem & Biol Engn, Hangzhou 310012, Peoples R China

[3] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

[4] Univ Nottingham Ningbo China, Dept Chem & Environm Engn, Ningbo 315100, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 21期

关键词：

HYDROGEN-DEUTERIUM EXCHANGE; NITROGEN-HETEROCYCLES; ISOTOPE-EXCHANGE; RHODIUM; ENHANCEMENT; TRITIUM;

D O I：

10.1039/d1cc07128a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A regioselective deuteration at the beta- and gamma-position of pyridines is reported. Efficient deuteration occurred with a combination of (KOBu)-Bu-t and DMSO-d(6), replenishing the prevailing alpha-deuteration of the pyridine systems. Preliminary mechanistic studies suggested that the dimsyl carbanion acts as one of the key intermediates.

引用

页码：3497 / 3500

页数：4

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