Bis-sesquiterpene from the Marine Sponge Dysidea fragilis

被引：0

作者：

Phan Van Kiem ^{[1
]}

Nguyen Xuan Nhiem ^{[1
]}

Bui Huu Tai ^{[1
]}

Hoang Le Tuan Anh ^{[1
]}

Dan Thi Thuy Hang ^{[1
]}

Nguyen Thi Cuc ^{[1
]}

Le Thi Huyen ^{[2
]}

Nguyen Hoai Nam ^{[1
]}

Pham Hai Yen ^{[1
]}

Do Cong Thung ^{[3
]}

Chau Van Minh ^{[1
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] VNU Univ Sci, Fac Chem, 334 Nguyen Trai, Hanoi, Vietnam

[3] VAST, Inst Marine Environm & Resources, 246 Danang, Ngo Quyen, Haiphong, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 04期

关键词：

Dysidea fragilis; Dysideidae; Dysinidin C; Dysinidin D; Dysinidin E; STEROIDS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new sesquiterpenes and one new bis-sesquiterpene, named dysinidins C-E (1-3) along with three known sterols, dysideasterol F, 9 alpha,11 alpha-epoxycholest-7-en-3 beta,5 alpha,6 alpha-triol, and 9 alpha,11 alpha-epoxycholest-7-en-3 beta,5 alpha,6 alpha,19-tetrol 6-acetate (4-6) were isolated from the Vietnamese marine sponge Dysidea fragilis (Montagu, 1814). Their structures were determined by ID- and 2D-NMR spectroscopies and HR-ESI-MS, as well as by comparison with reported literature data. Compounds 4-6 were found to inhibit eight human cancer cell lines (KB, LU-1, HL-60, LNCaP, SK-Mel-2, HepG-2, MCF-7, and PC-3), with IC50 values ranging from 7.3 to 31.5 mu M.

引用

页码：439 / 441

页数：3

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