Evaluation of Insulin-Like Growth Factor-1 in Indian Growth Hormone-Deficient Children on Growth Hormone Therapy

被引：4

作者：

Ekbote, Veena H. ^{[1
]}

Rustagi, Vaishakhi T. ^{[2
]}

Khadilkar, Vaman V. ^{[1
]}

Khadilkar, Anuradha V. ^{[1
]}

Chiplonkar, Shashi A.

机构：

[1] Jehangir Hosp, Growth & Pediat Endocrine Unit, Hirabai Cowasji Jehangir Med Res Inst, Pune 411001, Maharashtra, India

[2] Bharati Vidyapeeth Hosp, Pune, Maharashtra, India

来源：

ENDOCRINE RESEARCH | 2011年 / 36卷 / 03期

关键词：

IGF-1; Indian; GHD children; GH therapy; IGF-BINDING PROTEIN-3; GH;

D O I：

10.3109/07435800.2011.580443

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To evaluate the impact of recombinant human growth hormone therapy (GHT) on serum insulin-like growth factor 1 (IGF-1) concentrations in Indian children with growth hormone deficiency. Methods. Data on anthropometry and serum IGF-1 concentrations were collected from 28 growth hormone-deficient prepubertal children (8.6 +/- 2.9 years) on growth hormone therapy, 6 monthly over the period of 2 years. Results. Height z-scores showed a steady increase from baseline to 24 months. However, IGF-1 z-scores showed a plateau after the first 6 months and then a small dip followed by a rise. The pattern of increase of IGF-1 z-scores was dissimilar to that of the height z-scores. Conclusion. The change in serum IGF-1 z-scores in response to GHT in Indian children may not be a good indicator for monitoring growth hormone responsiveness.

引用

页码：109 / 115

页数：7

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