Effects of polymer modification of an anti-cancer drug with poly(ethylene oxide)

被引：9
|
作者：
Sohn, JS
Jo, BW
Hess, M
Schwark, K
Dehne, S
Zähres, M
机构：
[1] Univ Duisburg Essen, Dept Phys Chem, D-47048 Duisburg, Germany
[2] Chosun Univ, Dept Polymer Sci & Engn, Kwangju 501759, South Korea
[3] Chosun Univ, Dept New Mat Biol, Kwangju 501759, South Korea
来源：
MACROMOLECULAR SYMPOSIA | 2005年 / 225卷
关键词：
mPEG-paclitaxel; simulation; solution; structure;
D O I：
10.1002/masy.200550704
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The hydrophobic anti-cancer drug paclitaxel was modified with the hydrophilic poly(ethylene oxide) to a water-soluble predrug. The modification of the polymer chain results in a different solution behaviour of the macromolecules compared with the unmodified polymer. The phase diagram of the (quasi)binary system predrug-water was investigated, and molecular simulations of the predrug were executed in vacuum and in the presence of water. The results are important for further engineering on active drug systems.
引用
收藏
页码：31 / 42
页数：12
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