Recurrent MEF2D Fusions Define A New Subtype of Acute Lymphoblastic Leukemia Associated with Older Age at Diagnosis and Poor Outcome

被引：0

作者：

Gu, Z. ^{[1
]}

Liu, Y. ^{[2
]}

Roberts, K. ^{[1
]}

Shao, Y. ^{[3
]}

Harvey, R. ^{[4
]}

Chen, I. M. ^{[4
]}

Valentine, M. ^{[5
]}

Pei, D. ^{[1
]}

Marra, M. ^{[6
]}

Larsen, E. ^{[7
]}

Spinelli, O. ^{[8
]}

Minden, M. ^{[9
]}

Fielding, A. ^{[10
]}

Bhatia, R. ^{[11
]}

Stock, W. ^{[12
]}

Konopleva, M. ^{[13
]}

Willman, C. ^{[4
]}

Loh, M. ^{[14
]}

Hunger, S. ^{[15
]}

Mullighan, C. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Pathol, 332 N Lauderdale St, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Computat Biol, 332 N Lauderdale St, Memphis, TN 38105 USA

[4] Univ New Mexico, Ctr Canc, Albuquerque, NM 87131 USA

[5] St Jude Childrens Res Hosp, Cytogenet Core Facil, 332 N Lauderdale St, Memphis, TN 38105 USA

[6] BC Canc Agcy, Canadas Michael Smith Genome Sci Ctr, Vancouver, BC, Canada

[7] Maine Med Ctr, Inst Canc, Maine Childrens Canc Program, Scarborough, ME USA

[8] Papa Giovanni XXIII Hosp, Dept Haematol & Bone Marrow Transplantat, Bergamo, Italy

[9] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada

[10] UCL Canc Inst, Dept Haematol, London, England

[11] Univ Alabama Birmingham, Div Haematol & Oncol, Dept Med, Birmingham, AL USA

[12] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA

[13] Univ Texas MD Anderson Canc Ctr, Dept Leukaemia, Houston, TX 77030 USA

[14] Benioff Childrens Hosp, Dept Paediat, San Francisco, CA USA

[15] Childrens Hosp Philadelphia, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

PEDIATRIC BLOOD & CANCER | 2016年 / 63卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

O-034

引用

页码：S14 / S15

页数：2

共 39 条

[1] Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Zhaohui Gu
Michelle Churchman
Kathryn Roberts
Yongjin Li
Yu Liu
Richard C. Harvey
Kelly McCastlain
Shalini C. Reshmi
Debbie Payne-Turner
Ilaria Iacobucci
Ying Shao
I-Ming Chen
Marcus Valentine
Deqing Pei
Karen L. Mungall
Andrew J. Mungall
Yussanne Ma
Richard Moore
Marco Marra
Eileen Stonerock
Julie M. Gastier-Foster
Meenakshi Devidas
Yunfeng Dai
Brent Wood
Michael Borowitz
Eric E. Larsen
Kelly Maloney
Leonard A. Mattano Jr
Anne Angiolillo
Wanda L. Salzer
Michael J. Burke
Francesca Gianni
Orietta Spinelli
Jerald P. Radich
Mark D. Minden
Anthony V. Moorman
Bella Patel
Adele K. Fielding
Jacob M. Rowe
Selina M. Luger
Ravi Bhatia
Ibrahim Aldoss
Stephen J. Forman
Jessica Kohlschmidt
Krzysztof Mrózek
Guido Marcucci
Clara D. Bloomfield
Wendy Stock
Steven Kornblau
Hagop M. Kantarjian
Nature Communications, 7
[2] Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
Gu, Zhaohui
Churchman, Michelle
Roberts, Kathryn
Li, Yongjin
Liu, Yu
Harvey, Richard C.
McCastlain, Kelly
Reshmi, Shalini C.
Payne-Turner, Debbie
Iacobucci, Ilaria
Shao, Ying
Chen, I-Ming
Valentine, Marcus
Pei, Deqing
Mungall, Karen L.
Mungall, Andrew J.
Ma, Yussanne
Moore, Richard
Marra, Marco
Stonerock, Eileen
Gastier-Foster, Julie M.
Devidas, Meenakshi
Dai, Yunfeng
Wood, Brent
Borowitz, Michael
Larsen, Eric E.
Maloney, Kelly
Mattano, Leonard A., Jr.
Angiolillo, Anne
Salzer, Wanda L.
Burke, Michael J.
Gianni, Francesca
Spinelli, Orietta
Radich, Jerald P.
Minden, Mark D.
Moorman, Anthony V.
Patel, Bella
Fielding, Adele K.
Rowe, Jacob M.
Luger, Selina M.
Bhatia, Ravi
Aldoss, Ibrahim
Forman, Stephen J.
Kohlschmidt, Jessica
Mrozek, Krzysztof
Marcucci, Guido
Bloomfield, Clara D.
Stock, Wendy
Kornblau, Steven
Kantarjian, Hagop M.
NATURE COMMUNICATIONS, 2016, 7
[3] Genetic and clinical characteristics of acute B-cell lymphoblastic leukemia with MEF2D fusions and report of two novel MEF2D rearrangements
Cao, Han-Yu
Li, Hui-Ying
Cai, Wen-Zhi
Huang, Yuan-Hong
Qiu, Qiao-Cheng
Li, Zheng-
Xu, Yang
Xue, Sheng-Li
Dai, Hai-Ping
ANNALS OF HEMATOLOGY, 2024, 103 (10) : 4155 - 4161
[4] Outcome and molecular measurable residual disease monitoring in adult B-cell acute lymphoblastic leukemia patients with MEF2D fusions
Sun, Kai
Chen, Wen-Min
Wang, Xu
Zhao, Xiao-Su
Li, Ling-Di
Hao, Yue
Wang, Jun
Xu, Nan
Jiang, Qian
Jiang, Hao
Xu, Lan-Ping
Wang, Yu
Zhang, Xiao-Hui
Huang, Xiao-Jun
Qin, Ya-Zhen
HEMATOLOGICAL ONCOLOGY, 2023, 41 (03) : 594 - 597
[5] Outcome and Molecular Measurable Residual Disease Monitoring in Adult B-Cell Acute Lymphoblastic Leukemia Patients with MEF2D Fusions
Sun, Kai
Chen, Wen-Min
Wang, Xu
Zhao, Xiao-Su
Li, Ling-Di
Hao, Yue
Wang, Jun
Xu, Nan
Jiang, Hao
Xu, Lan-Ping
Wang, Yu
Zhang, Xiao-Hui
Jiang, Qian
Huang, Xiao Jun
Qin, Ya-Zhen
BLOOD, 2022, 140 : 11864 - 11865
[6] Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia
Chang, Ning
Feng, Jianhua
Liao, Peiyun
Hu, Yuxing
Li, Meifang
He, Yanjie
Li, Yuhua
TRANSLATIONAL CANCER RESEARCH, 2023, 12 (02) : 287 - +
[7] Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia
V Prima
S P Hunger
Leukemia, 2007, 21 : 2470 - 2475
[8] Cooperative transformation by MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins generated by the variant t(1;19) in acute lymphoblastic leukemia
Prima, V.
Hunger, S. P.
LEUKEMIA, 2007, 21 (12) : 2470 - 2475
[9] B-cell acute lymphoblastic leukemia with MEF2D::BCL9 rearrangement mimicking a Burkitt lymphoma
Chevalier, Simon
Legrand, Clementine
BLOOD, 2024, 144 (19)
[10] PAX5 FUSIONS ARE RECURRENT AND ASSOCIATED TO POOR OUTCOME IN MLL-GERMLINE INFANT B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA
Fazio, G.
Grioni, A.
De Lorenzo, P.
Quadri, M.
Pedace, L.
Corral, L.
Palamini, S.
Bardini, M.
Buldini, B.
Locatelli, F.
Valsecchi, M. G.
Biondi, A.
Cazzaniga, G.
HAEMATOLOGICA, 2020, 105 : S47 - S48

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