Effects of Short-Course Zidovudine on the Selection of Nevirapine-Resistant HIV-1 in Women Taking Single-Dose Nevirapine

被引：6
|
作者：
Micek, Mark A. [1 ,2 ]
Blanco, Ana Judith [1 ,2 ]
Carlsson, Jacquelyn [3 ]
Beck, Ingrid A. [3 ]
Dross, Sandra [3 ]
Matunha, Laurinda [2 ]
Seidel, Kristy [3 ]
Montoya, Pablo [1 ,2 ]
Gantt, Soren [1 ,3 ]
Matediana, Eduardo
Jamisse, Lilia [4 ]
Gloyd, Stephen [1 ,2 ]
Frenkel, Lisa M. [1 ,3 ]
机构：
[1] Univ Washington, Seattle, WA 98195 USA
[2] Hlth Alliance Int, Seattle, WA USA
[3] Seattle Childrens Res Inst, Seattle, WA USA
[4] US Agcy Int Dev, Washington, DC 20523 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2012年 / 205卷 / 12期
基金：
美国国家卫生研究院;
关键词：
TO-CHILD TRANSMISSION; PREVENTION; MUTATIONS; THERAPY; PLACEBO; MOTHERS;
D O I：
10.1093/infdis/jis282
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Single-dose nevirapine (sdNVP) given to prevent mother-to-child-transmission of HIV-1 selects NVP-resistance. Short-course zidovudine (ZDV) was hypothesized to lower rates of NVP-resistance. HIV-1 infected pregnant women administered sdNVP with or without short-course ZDV were assessed for HIV-1 mutations (K103N, Y181C, G190A, and V106M) prior to delivery and postpartum. Postpartum NVP-resistance was lower among 31 taking ZDV+sdNVP compared to 33 taking only sdNVP (35.5% vs 72.7%; chi(2) P=.003). NVP mutants decayed to <2% in 24/35 (68.6%) at a median 6 months postpartum, with no differences based on ZDV use (logrank P=.99). Short-course ZDV was associated with reduced NVP-resistance mutations among women taking sdNVP.
引用
收藏
页码：1811 / 1815
页数：5
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