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- [8] 17 β-estradiol (E2) up-regulates the expression of peroxisome proliferator-activated receptors (PPAR), down-regulates the expression of ICAM-1, VCAM-1 and E-selectin, and attenuates angiotensin II (Ang II)-induced abdominal aortic aneurysm (AAA) in apolipoprotein E deficient (ApoE-KO) mice [J]. CIRCULATION, 2001, 104 (17) : 91 - 91