Reversible sol-gel transitions in aqueous solutions of N-isopropylacrylamide ionic copolymers

被引：9
|
作者：
Krzyminski, Karol J. [1 ]
Jasionowski, Marek [1 ]
Gutowska, Anna [1 ]
机构：
[1] Pacific NW Natl Lab, Richland, WA 99354 USA
来源：
POLYMER INTERNATIONAL | 2008年 / 57卷 / 04期
关键词：
thermo-responsive polymers; sol-gel transition; N-isopropylacrylamide; ionic copolymers;
D O I：
10.1002/pi.2318
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Ionic copolymers of N-isopropylacrylamide (NIPA) exhibiting sol-gel transitions in aqueous solutions were investigated. The studies were aimed at understanding of the structure-property relationship in the design of injectable, in situ forming gels for potential biomedical applications in delivery of therapeutics and tissue engineering. Aqueous solutions of NIPA ionic copolymers were found to flow freely at ambient temperatures and formed soft gels with controlled syneresis above 32 degrees C, the lower critical solution temperature of NIPA. The sol-gel transitions and temperature-dependent properties of the resulting gels were analyzed using dynamic rheometry and ultraviolet and infrared spectrometry, and were found to be controlled by the molecular weight and composition of copolymers, ionization state of comonomers and composition of aqueous solvent. (c) 2008 Society of Chemical Industry.
引用
收藏
页码：592 / 604
页数：13
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