In this paper, the comparative analysis method is used to compare the relation between the key comprehensive university and local medical college, medical physics experiment course. The results show that there are many factors, in the subjective and objective, cause the same one course having the different form and the effect of the learning. Then, we discuss these factors in detail from many aspects. Combined with the current policy of promoting the transformation of local colleges by china education department in 2014, this paper also discusses how to integrate the application of the type, skills of the "medical physics experiment" course teaching reform. Throughout this paper, we can find that the actual situation of medical physics experiment course is very bad, but, under the national new policy of transformation, the reform of medical physics experiment teaching in local medical college has encountered an unprecedented good opportunity.