Very early expression of vascular endothelial growth factor in brain oedema tissue associated with brain contusion

被引：0
|
作者：
Suzuki, R [1 ]
Fukai, N [1 ]
Nagashijma, G [1 ]
Asai, J [1 ]
Itokawa, H [1 ]
Nagai, M [1 ]
Suzuki, T [1 ]
Fujimoto, T [1 ]
机构：
[1] Showa Univ, Fujigaoka Hosp, Dept Neurosurg, Tokyo, Japan
来源：
BRAIN EDEMA XII | 2003年 / 86卷
关键词：
cerebral contusion; oedema; VEGF; KDR;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background. Brain oedema associated with cerebral contusion can be life-threatening. Mechanisms of the development of brain oedema are still unclear. Method. We investigated the expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (KDR/Flk-1) in the contusional brain tissue obtained during neurosurgery from 5 patients. Findings. VEGF is expressed in some but not all the astrocytes, and KDR/Flk-1 is expressed in vascular endothelial cells in the contusional tissue as early as 3 hours after onset. Conclusion. The results suggested that the VEGF is induced in the contusional tissue in the very early period after onset, and that it increases capillary permeability via KDR/Flk-1 resulting in vasogenic type brain oedema.
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页码：277 / 279
页数：3
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