Efficacy of prolonged valganciclovir therapy for congenital cytomegalovirus infection

被引：6
|
作者：
Kashiwagi, Yasuyo [1 ]
Kawashima, Hisashi [1 ]
Nakajima, Junya [1 ]
Ishida, Yu [1 ]
Nishimata, Shigeo [1 ]
Miyajima, Tasuku [1 ]
Takekuma, Kouji [1 ]
Hoshika, Akinori [1 ]
Inoue, Naoki [2 ]
机构：
[1] Tokyo Med Univ, Dept Pediat, Shinjuku Ku, Tokyo, Japan
[2] Natl Inst Infect Dis, Dept Virol 1, Shinjuku Ku, Tokyo, Japan
来源：
JOURNAL OF INFECTION AND CHEMOTHERAPY | 2011年 / 17卷 / 04期
关键词：
Cytomegalovirus (CMV); Valganciclovir (VGCV); Magnetic resonance (MR) imaging; Congenital infection; GANCICLOVIR THERAPY; HEARING;
D O I：
10.1007/s10156-010-0204-z
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We report prolonged valganciclovir (VGCV) treatment of a symptomatic cytomegalovirus infection case. Automated auditory brainstem evoked response performed at 5 days of age revealed severe hearing impairment. Cranial magnetic resonance (MR) imaging at 11 days of age showed abnormal findings. At 5 weeks of age, VGCV was started. The viral load in blood cells, plasma, and urine decreased during the 6-week treatment. Because of improvement of hearing level and no adverse effects, VGCV was restarted for an additional 6 weeks. Neither the patient's hearing impairment nor results of cranial MR imaging have become worse in 6 months. It is crucial to gather information from as many cases as possible treated with VGCV to establish a standard protocol for VGCV treatment.
引用
收藏
页码：538 / 540
页数：3
相关论文
共 50 条
  • [1] Prolonged treatment with valganciclovir in an infant with congenital cytomegalovirus infection
    Baquero-Artigao, F.
    Romero Gomez, M. P.
    [J]. ANALES DE PEDIATRIA, 2009, 70 (06): : 578 - 581
  • [2] Valganciclovir for treatment of congenital cytomegalovirus infection
    Schulzke, Sven
    Buehrer, Christoph
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 2006, 165 (08) : 575 - 576
  • [3] Valganciclovir for treatment of congenital cytomegalovirus infection
    Sven Schulzke
    Christoph Bührer
    [J]. European Journal of Pediatrics, 2006, 165 : 575 - 576
  • [4] Hematologic Adverse Events Associated With Prolonged Valganciclovir Treatment in Congenital Cytomegalovirus Infection
    Ziv, Liron
    Yacobovich, Joanne
    Pardo, Joseph
    Yarden-Bilavsky, Havatzelet
    Amir, Jacob
    Osovsky, Micky
    Bilavsky, Efraim
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2019, 38 (02) : 127 - 130
  • [5] Efficacy, safety, and pharmacokinetics of oral valganciclovir in patients with congenital cytomegalovirus infection
    Suganuma, Eisuke
    Sakata, Hideaki
    Adachi, Nodoka
    Asanuma, Satoshi
    Furuichi, Mihoko
    Uejima, Yoji
    Sato, Satoshi
    Abe, Tomoya
    Matsumoto, Daigo
    Takahashi, Ryohei
    Yamamoto, Sachi
    Kawano, Yutaka
    Arai, Takashi
    Oh-ishi, Tsutomu
    [J]. JOURNAL OF INFECTION AND CHEMOTHERAPY, 2021, 27 (02) : 185 - 191
  • [6] Oral valganciclovir treatment for congenital cytomegalovirus infection
    Imamura, Takashi
    Suzutani, Tatsuo
    Ogawa, Hiroshi
    Asano, Kimisato
    Nomoto, Mika
    Matsui, Takamichi
    Momoi, Nobuo
    Ikuta, Kazufumi
    Inoue, Naoki
    Hosoya, Mitsuaki
    [J]. PEDIATRICS INTERNATIONAL, 2011, 53 (02) : 249 - 252
  • [7] Treatment of symptomatic congenital cytomegalovirus infection with valganciclovir
    Jansen, CFM
    Toet, MC
    Rademaker, CMA
    Ververs, TFF
    Gerards, LJ
    van Loon, AM
    [J]. JOURNAL OF PERINATAL MEDICINE, 2005, 33 (04) : 364 - 366
  • [8] Valganciclovir therapy for a neonate with congenital cytomegalovirus pneumonitis
    Kanda, Riko
    Shimizu, Daisuke
    Hoshina, Takayuki
    Ogawa, Masato
    Kusuhara, Koichi
    [J]. PEDIATRICS INTERNATIONAL, 2021, 63 (12) : 1526 - 1528
  • [9] Valganciclovir for Congenital Cytomegalovirus
    Schornagel, Fleurtje A.
    Oudesluys-Murphy, Anne M.
    Vossen, Ann C.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (25): : 2462 - 2462
  • [10] Efficacy and Safety of Valganciclovir in Congenital Cytomegalovirus Infection with Isolated Intrahepatic Cholestasis: A Randomized Controlled Trial
    Mahmud, Salahuddin
    Farhana, Tanzila
    Anik, Ataul Mustufa
    Ahmed, Fayaza
    Parvez, Mashud
    Baidya, Madhabi
    Rashid, Rafia
    Tasneem, Farhana
    Hasan, Ahmed Rashidul
    Alam, Mohammad Jahangir
    Muaz, Shafi Ahmed
    [J]. PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION, 2024, 27 (05) : 298 - 312
12345