Rapamycin Enhances the Suppressive Capacity of Ex Vivo Expanded Regulatory T Cells (Tregs) Isolated From Pediatric Thymus

被引:0
|
作者
Dijke, E. [1 ]
Hoeppli, R. [2 ]
Ellis, T. [1 ]
Pearcey, J. [1 ]
Larsen, I. [1 ]
Rebeyka, I. [1 ]
Ross, D. [3 ]
Levings, M. [2 ]
West, L. [1 ]
机构
[1] Univ Alberta, Alberta Transplant Inst, Pediat, Edmonton, AB, Canada
[2] Univ British Columbia, Surg, Vancouver, BC V5Z 1M9, Canada
[3] Univ Alberta, Alberta Transplant Inst, Surg, Edmonton, AB, Canada
来源
关键词
D O I
10.1016/j.healun.2015.01.397
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
383
引用
收藏
页码:S147 / S148
页数:2
相关论文
共 50 条
  • [1] Ex Vivo Expansion With Rapamycin Enhances the Suppressive Function of Regulatory T Cells (Tregs) Isolated from Pediatric Thymus
    Dijke, E.
    Hoeppli, R.
    Ellis, T.
    Pearcey, J.
    Larsen, I.
    Rebeyka, I.
    Ross, D.
    Levings, M.
    West, L.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2015, 15
  • [2] POTENT SUPPRESSION OF ALLOGENEIC AND XENOGENEIC IMMUNITY BY CRYOPRESERVED REGULATORY T CELLS (TREGS) ISOLATED AND EXPANDED FROM HUMAN THYMUS.
    Dijke, Esme
    Hoeppli, Romy
    Seeberger, Karen
    Larsen, Ingrid
    Rebeyka, Ivan
    Ross, David
    Korbutt, Gregory
    Levings, Megan
    West, Lori
    TRANSPLANTATION, 2015, 99 (11) : S44 - S44
  • [3] Regulatory T cells (Tregs) GMP manufacture for clinical application: generation of a high number of stable and functional ex vivo expanded Tregs
    Ulbar, F.
    Catani, L.
    Montemurro, T.
    Vigano, M.
    Lavazza, C.
    Cavo, M.
    Giordano, R.
    Arpinati, M.
    Lemoli, R. M.
    BONE MARROW TRANSPLANTATION, 2016, 51 : S117 - S117
  • [4] Allogeneic and Xenogeneic Immunity Is Potently Suppressed by Expanded Regulatory T Cells (Tregs) from Human Thymus
    Dijke, E.
    Hoeppli, R.
    Seeberger, K.
    Larsen, I.
    Rebeyka, I.
    Ross, D.
    Korbutt, G.
    Levings, M.
    West, L.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2016, 35 (04): : S187 - S187
  • [5] Migratory properties of ex vivo expanded regulatory T cells: Influence of all-trans retinoic acid and rapamycin
    Beermann, J. L.
    Thiesler, C. T.
    Dringenberg, U.
    Alter, C.
    Kuhs, S.
    Velaga, S.
    Ukena, S. N.
    Franzke, A.
    TRANSPLANT IMMUNOLOGY, 2017, 45 : 29 - 34
  • [6] Low Dose Rapamycin Treatment Increases the Ability of Ex Vivo Expanded Human Regulatory T Cells To Inhibit Transplant Arteriosclerosis In Vivo
    Nadig, S. N.
    Hester, J.
    Schiopu, A.
    Wood, K. J.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 : 66 - 66
  • [7] In vivo prevention of transplant arteriosclerosis by ex vivo–expanded human regulatory T cells
    Satish N Nadig
    Joanna Więckiewicz
    Douglas C Wu
    Gregor Warnecke
    Wei Zhang
    Shiqiao Luo
    Alexandru Schiopu
    David P Taggart
    Kathryn J Wood
    Nature Medicine, 2010, 16 : 809 - 813
  • [8] IL2 and Rapamycin Enhance Persistence of Adoptively-Transferred Ex-Vivo Expanded T Regulatory Cells
    Furlan, Scott N.
    Lopez, Christina
    Tkachev, Victor
    Betz, Kayla
    Hunt, Daniel J.
    Hibbard, James
    Blazar, Bruce R.
    Trapnell, Cole
    Kean, Leslie
    BLOOD, 2018, 132
  • [9] Repertoire analysis of ex vivo polyclonally expanded regulatory T cells.
    Zilberberg, Jenny
    Goldgirsh, Kira
    Komgold, Robert
    Friedman, Thea M.
    BLOOD, 2006, 108 (11) : 919A - 920A
  • [10] Extracellular Vesicles Derived From Ex Vivo Expanded Regulatory T Cells Modulate In Vitro and In Vivo Inflammation
    Thome, Aaron D.
    Thonhoff, Jason R.
    Zhao, Weihua
    Faridar, Alireza
    Wang, Jinghong
    Beers, David R.
    Appel, Stanley H.
    FRONTIERS IN IMMUNOLOGY, 2022, 13