Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

被引：10
|
作者：
Yang, K
Feng, YP
Li, YQ [1 ]
机构：
[1] Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China
[2] Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China
来源：
BRAIN RESEARCH | 2001年 / 900卷 / 02期
基金：
中国国家自然科学基金;
关键词：
baclofen; substantia gelatinosa; spinal cord; whole-cell voltage-clamp recording; inhibitory postsynaptic current; rat;
D O I：
10.1016/S0006-8993(01)02293-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated the action of baclofen, an agonist for GABA(B) receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by A delta fibers. Baclofen (10 muM) reduced the amplitude of A delta fiber-evoked glycine receptor-mediated IPSCs to 20.9+/-3.0% (n = 13), and GABA(A) receptor-mediated IPSCs to 18.6+/-3.4% (n = 12) of the controls, respectively. The results further suggest modulatory role of GABA(B) receptor in spinal dorsal hem. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：320 / 323
页数：4
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