Off-line design of PAT systems for on-line applications

In the manufacturing industry, for example, the pharmaceutical industry, a thorough understanding of the process is necessary in addition to a properly designed monitoring and analysis system (PAT system) to consistently obtain the desired end-product properties. A model-based computer-aided framework including the methods and tools through which the design of monitoring and analysis systems for product quality control can be generated, analyzed and/or validated, has been developed. Two important supporting tools within the framework are a knowledge base and a model library. The knowledge base provides the necessary information/data during the design of the PAT system and the model library generates additional or missing data needed for design. Optimization of the PAT system design can be achieved in terms of product data analysis time and/or cost of monitoring equipment subject to the maintenance of the desired product quality.