High-throughput high-performance liquid chromatography/mass spectrometry for modern drug discovery

被引：49
|
作者：
Kyranos, JN [1 ]
Cai, H [1 ]
Wei, D [1 ]
Goetzinger, WK [1 ]
机构：
[1] Arqule Inc, Woburn, MA 01801 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2001年 / 12卷 / 01期
关键词：
D O I：
10.1016/S0958-1669(00)00176-2
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
High-throughput high-performance liquid chromatography/mass spectrometry can be used in the analysis of high-throughput organic synthesis products, bioanalytical target analysis for preclinical and clinical studies, and early absorption, distribution, metabolism and excretion (ADME) screening. New techniques are emerging, including system automation, faster analysis, programmed multiple extraction and analysis columns, multiple electrospray ionization channels, and automated 96-well sample preparation.
引用
收藏
页码：105 / 111
页数：7
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