Validity of PSA, free/total PSA ratio and complexed/total PSA ratio measurements in men with acute urinary retention

被引：1

作者：

Sriprasad, S

Dew, TK

Muir, GH

Thompson, PM

Mulvin, D

Choi, WH

Dickinson, IK

Sherwood, RA

机构：

[1] Kings Coll Hosp London, Dept Urol, London SE5 9RS, England

[2] Kings Coll Hosp London, Dept Clin Biochem, London, England

[3] Joyce Green Hosp, Dept Urol, Dartford, Kent, England

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2001年 / 4卷 / 03期

关键词：

urinary retention; PSA; free/total and complexed/total PSA ratios;

D O I：

10.1038/sj.pcan.4500530

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The reliability of serum prostate specific antigen (PSA) measurements in men with acute urinary retention is unclear. Total PSA, free and complexed PSA were measured, and the free/total (f/t) PSA and complexed/total (c/t) PSA ratios calculated, prior to catheterisation and at 48 and 72 h post-catheterisation in 39 men with acute retention. Subsequent histology showed 12 patients had prostate cancer and 27 benign prostatic hypertrophy. Serum free and total PSA fell following catheterisation, while complexed PSA rose during the first 48 h then subsequently fell. The f/t PSA and c/t PSA ratios provided the best discrimination at 48-72 h with 100% sensitivity and 75-82% specificity.

引用

页码：167 / 172

页数：6

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